Tertiary institutions of learning generate a substantial amount of research and development. However, the majority of these do not make it to market and remain mostly theoretical. There is a need to establish technology transfer offices at these institutions to increase the level of commercialization of research and development at the institutional level. This masterplan proposes to establish a world class TTO at tertiary institutions of learning and research centers. The TTOs are also intended to offer an additional revenue stream for the universities, TVETs and research centers. This initiative will be implemented in collaboration with members of the KNEIL network. The TTOs are expected to inspire innovators at these institutions to invest in generation of research and development with the confidence that they will have the necessary resources to bring knowledge output to market. The TTOs will be expected to develop a minimum criterion of the innovation to determine those that would receive support from the TTO. This minimum criterion will be aspirational to innovators’ institution to raise the quality of their inventions in search of globally competitive solutions.